Already over a decade old, Granular Synthesis' 1996 installation 'Modell 5' still makes for an incredibly intense audiovisual experience. It was shown at V2 during this year's Exploding Cinema section of the Film Festival Rotterdam, themed Free Radicals.
Consisting of four large screens, each showing the face of Japanese performance artist Akemi Takeya, the piece is a 40 minutes long digital manipulation of facial expressions and movements synchronized with heavy beats and raging sound effects. The result is devilishly visceral, deconstructing the most familiar of images - the human face - into a relentless rythm of alien shapes. As the IFFR program described it, 'Modell 5' "evokes a feeling of schizophrenia, as if the body is being torn apart and merged with the electronic space."
The only other work I can think of that achieves a similar intensity is Chris Cunningham's music video for Aphex Twin's 'Come to Daddy'. Imagine watching that for 40 minutes on a screen so large you can't escape from it. Pure perceptional overload.